NEPTUNE clinical study
Living with Chronic Eye Pain?
Learn about the NEPTUNE clinical study evaluating an investigational treatment for Neuropathic Corneal Pain (NCP).
Neuropathic corneal pain can cause persistent pain, burning, stinging, or discomfort in the eyes, even when the eye looks relatively normal. This study is evaluating the safety and potential effectiveness of an investigational eye drop for adults with neuropathic corneal pain.
Now enrolling
About the Study
About the NEPTUNE Study
What is NCP?
Neuropathic corneal pain (NCP) is a chronic condition where nerves in the cornea become overly sensitive or damaged, leading to ongoing eye pain and discomfort. Common symptoms include:
Burning, stinging, or shooting pain in the eyes
Sensitivity to light (photophobia)
Foreign body sensation or dryness
Blurry or fluctuating vision
Persistent pain
Study Purpose
The NEPTUNE study is being conducted to evaluate the safety and potential effectiveness of an investigational treatment (urcosimod eye drops).
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Study Overview
The NEPTUNE study (Neuropathic Eye Pain Treatment with Urcosimod & Nerve Evaluation) is a clinical research study evaluating an investigational eye drop for adults with neuropathic corneal pain.
This is a randomized, placebo-controlled study. This means that if you qualify and choose to participate, you will be randomly assigned (like a flip of a coin) to receive either the investigational treatment or a placebo (inactive eye drop that looks the same), and neither you nor the study team will know which one is being administered for the entire duration of the study.
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Treatment Plan
Design
Participants are randomly assigned to receive either urcosimod eye drops or placebo eye drops, instilled 4 times per day.
Duration
The treatment period is ~12 weeks, with follow-up visits for monitoring. Participation in the study will last for ~17 weeks.
Visits
Regular study visits include eye examinations and other assessments to evaluate safety and study outcomes. Procedures are non-invasive or standard ophthalmic tests.
All study-related procedures, including the investigational drops, is provided at no cost to participants.
Am I Eligible
Eligibility Criteria
Eligibility will be assessed by participating study team. You may want to reach out if you are an adult 18 years or older and have been diagnosed with neuropathic corneal pain.
Exclusion Criteria
A study doctor will review your medical history and perform screening tests to determine eligibility.
18+
You can view the study criteria on clinicaltrials.gov using the study identifier NCT07838506.
Trial Locations
Find a Study Location
The NEPTUNE study will be conducted at multiple clinical sites across the United States and Europe, including Italy, Spain, and France.
To find out if a study location is near you or to learn more, contact a participating site directly.
UNited States
Bascom Palmer Eye Institute
900 NW 17th Street, Miami, Florida 33136
UNited States
University of South Florida
13330 USF Laurel Drive, 4th Floor, Tampa, FL, 33612
UNited States
New York University Langone
222 East 41st Street, 4th Floor, NY, NY 10017
UNited States
University of Pennsylvania, Scheie Eye Institute
51 N 39th Street, Philadelphia, PA 19104
UNited States
Toyos Eye Clinic
4200 Stammer Place, Nashville, TN 37215
UNited States
Baylor College of Medicine, Alkek Eye Center
1977 Butler Blvd, 2nd Floor, Houston, TX 77030
UNited States
University of California Irvine, Gavin Herbert Eye Institute
850 Health Sciences Road, Irvine CA 92697-4375
UNited States
Boston Medical Center
1 Boston Medical Center Place, Boston, MA 02118
Spain
Instituto de Oftalmobiología Aplicada University of Valladolid
Edificio IOBA, Campus Miguel Delibes. Paseo Belen 17. 47011 Valladolid, Spain
Italy
Policlinico Umberto I
Viale del Policlinico, 155 – Rome, Italy
Italy
University of Rome
University Hospital, Via Álvaro del Portillo, 200, 00128 Roma RM, Italy
France
Hopital Fondation A de Rothschild
25 Rue Manin, 75019 Paris, France
Italy
Universitaria Careggi
Largo Brambilla 3, 50134 Florence, Italy
Not yet recruiting
Contact
Rosa Perna
Matilde Conforti
Contact
For general questions about the NEPTUNE study or to express interest in participating, please reach out to a clinical study site near you.
FAQs
Frequently Asked Questions
What is a clinical trial?
A clinical trial is a research study conducted with patients and designed to evaluate the safety and effectiveness of a new treatment. A trial helps determine whether a new therapy is safe and works as intended.
What if I don’t see a study site near me?
please contact the study location listed that is closest to you
How long will I be in the study?
Up to 17 weeks
Who is conducting the trial?
OKYO Pharma